{"id":12352,"date":"2025-01-24T21:30:38","date_gmt":"2025-01-24T14:30:38","guid":{"rendered":"https:\/\/chgcancercenter.com\/?p=12352"},"modified":"2025-01-28T23:43:00","modified_gmt":"2025-01-28T16:43:00","slug":"tace-liver-cancer-treatment","status":"publish","type":"post","link":"https:\/\/chgcancercenter.com\/en\/tace-liver-cancer-treatment\/","title":{"rendered":"In-Depth Analysis Why TACE Fails in Treating Liver Cancer?"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"12352\" class=\"elementor elementor-12352\">\n\t\t\t\t<div class=\"elementor-element elementor-element-53eb7dc6 e-flex e-con-boxed e-con e-parent\" data-id=\"53eb7dc6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1995faba elementor-widget elementor-widget-text-editor\" data-id=\"1995faba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h1><span style=\"font-size: 24pt;\"><strong>In-Depth Analysis Why TACE Fails in Treating Liver Cancer?<\/strong><\/span><\/h1><p class=\"translation-block\">Transarterial Chemoembolization (TACE) is a treatment for Hepatocellular Carcinoma (HCC) where chemotherapy drugs are injected into the hepatic artery that supplies the tumor, followed by embolization to block the blood flow. This process restricts the tumor\u2019s growth and destroys cancer cells.<\/p><p class=\"translation-block\">Why TACE May Not Be Effective in Some Patients<\/p><h2><span style=\"font-size: 18pt;\"><b>1. Tumor Characteristics<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Large or Multiple Tumors:<\/b><b><br \/><\/b><span style=\"font-weight: 400;\">TACE may be less effective in patients with large or multiple liver tumors, making complete tumor destruction difficult.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Portal Vein Invasion:<\/b><b><br \/><\/b><span style=\"font-weight: 400;\">If cancer has invaded the portal vein, embolization may cause liver failure due to blocked blood flow.<\/span><\/li><\/ul><h2><span style=\"font-size: 18pt;\"><b>2. Abnormal Liver Blood Flow<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Neoangiogenesis (New Blood Vessel Formation):\nTumors may develop new blood vessels, allowing them to receive nutrients despite embolization.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Abnormal or Venous Connections:<\/b><b><br \/><\/b><span style=\"font-weight: 400;\">Abnormal blood vessels can prevent chemotherapy drugs from reaching the tumor effectively.<\/span><\/li><\/ul><h2><span style=\"font-size: 18pt;\"><b>3. Liver Function Condition<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Severe Cirrhosis (Child-Pugh C):<\/b><b><br \/><\/b><span style=\"font-weight: 400;\">Patients with advanced cirrhosis may not tolerate TACE and face higher risks of complications.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Impaired Liver Recovery:<\/b><b><br \/><\/b><span style=\"font-weight: 400;\">Poor liver function can hinder recovery after TACE, leading to poor treatment outcomes.<\/span><\/li><\/ul><h2><span style=\"font-size: 18pt;\"><b>4. Chemotherapy Resistance<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Drug Resistance:<\/b><b><br \/><\/b><span style=\"font-weight: 400;\">Tumors resistant to chemotherapy used in TACE will reduce treatment effectiveness.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Inappropriate Drug Selection:<\/b><b><br \/><\/b><span style=\"font-weight: 400;\">Mismatched chemotherapy drugs or incorrect dosages can lead to ineffective treatment.<\/span><\/li><\/ul><h2><span style=\"font-size: 18pt;\"><b>5. Frequent TACE Sessions<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Repeated TACE:<\/b><b><br \/><\/b><span style=\"font-weight: 400;\">Multiple TACE procedures can damage healthy liver tissue, reducing liver function and limiting future treatment options.<\/span><\/li><\/ul><h2><span style=\"font-size: 18pt;\"><b>6. Improper Patient Selection<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Advanced Cancer Stage:<\/b><b><br \/><\/b><span style=\"font-weight: 400;\">TACE is less beneficial for patients with metastatic cancer or extensive disease.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><b>Poor Overall Health:<\/b><b><br \/><\/b><span style=\"font-weight: 400;\">Weak or multi-disease patients may not tolerate TACE well.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-03fc15b e-flex e-con-boxed e-con e-parent\" data-id=\"03fc15b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-36c3cc6 elementor-widget elementor-widget-text-editor\" data-id=\"36c3cc6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><span style=\"color: #000000; font-size: 18pt;\"><b>Management Strategies When TACE Fails<\/b><\/span><\/h2><p><span style=\"color: #000000;\"><b>Alternative Treatments:<\/b><\/span><\/p><ul><li class=\"translation-block\">Targeted Therapy: Sorafenib, Lenvatinib<\/li><li class=\"translation-block\">Immunotherapy: Atezolizumab + Bevacizumab<\/li><li><span style=\"font-weight: 400; color: #000000;\">Transarterial Radioembolization (TARE): Using radioactive beads to target tumors.<\/span><\/li><\/ul><p><span style=\"color: #000000;\"><b>Monitoring and Support:<\/b><\/span><\/p><ul><li><span style=\"font-weight: 400; color: #000000;\">Regular Liver Function Tests (LFTs) and tumor assessments.<\/span><\/li><\/ul><p><span style=\"color: #000000;\"><b>Palliative Care<\/b><\/span><\/p><ul><li><span style=\"font-weight: 400; color: #000000;\">To relieve symptoms and maintain quality of life in cases where aggressive treatment is not possible.<\/span><\/li><\/ul><p class=\"translation-block\">TACE is effective for intermediate-stage liver cancer but not suitable for all patients. Success depends on tumor size, liver function, and overall health. If TACE is ineffective, alternative treatments can be considered for better outcomes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ab05c0b e-flex e-con-boxed e-con e-parent\" data-id=\"ab05c0b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-705211d elementor-widget elementor-widget-video\" data-id=\"705211d\" data-element_type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=1itdSz5INiU&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-32e8f1d e-flex e-con-boxed e-con e-parent\" data-id=\"32e8f1d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18e9011 elementor-widget elementor-widget-ct_text_editor\" data-id=\"18e9011\" data-element_type=\"widget\" data-widget_type=\"ct_text_editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"ct_text_editor-18e9011\" class=\"ct-text-editor wow fadeInUp\" data-wow-delay=\"ms\">\n\t<div class=\"ct-item--inner\">\n\t\t<div class=\"ct-inline-css\"  data-css=\"\t        \t\t\t\">\n\n\t    <\/div>\n\t\t<div class=\"ct-text-editor elementor-clearfix\">\n\t\t\t<p class=\"translation-block\">For inquiry, please call <a href=\"tel:0638166058\" target=\"_self\">+66638166058<\/a><\/p>\t\t\n\t\t<\/div>\n\t<\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc4a6ee e-flex e-con-boxed e-con e-child\" data-id=\"cc4a6ee\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c0616b5 e-con-full e-flex e-con e-child\" data-id=\"c0616b5\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e7c50bd elementor-widget elementor-widget-text-editor\" data-id=\"e7c50bd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-family: lineseedsansth;\">Request consultation for treatment plan<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9058c76 e-con-full e-flex e-con e-child\" data-id=\"9058c76\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d1e4874 elementor-widget elementor-widget-text-editor\" data-id=\"d1e4874\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/lin.ee\/sx9JJLJ\"><img decoding=\"async\" class=\"\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/th.png\" alt=\"\u0e40\u0e1e\u0e34\u0e48\u0e21\u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e19\" width=\"115\" height=\"36\" border=\"0\" \/><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-549157e e-flex e-con-boxed e-con e-child\" data-id=\"549157e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u0e17\u0e33\u0e04\u0e27\u0e32\u0e21\u0e40\u0e02\u0e49\u0e32\u0e43\u0e08\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e15\u0e31\u0e1a\u0e14\u0e49\u0e27\u0e22 TACE \u0e1e\u0e23\u0e49\u0e2d\u0e21\u0e1b\u0e31\u0e08\u0e08\u0e31\u0e22\u0e17\u0e35\u0e48\u0e17\u0e33\u0e43\u0e2b\u0e49\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e44\u0e21\u0e48\u0e44\u0e14\u0e49\u0e1c\u0e25 \u0e41\u0e25\u0e30\u0e41\u0e19\u0e27\u0e17\u0e32\u0e07\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e40\u0e1e\u0e34\u0e48\u0e21\u0e40\u0e15\u0e34\u0e21\u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e1c\u0e25\u0e25\u0e31\u0e1e\u0e18\u0e4c\u0e17\u0e35\u0e48\u0e14\u0e35\u0e22\u0e34\u0e48\u0e07\u0e02\u0e36\u0e49\u0e19<\/p>","protected":false},"author":2,"featured_media":12361,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[64],"tags":[62,901,902,113,384,904,906,338,97,905,67,260,93,903,90],"class_list":["post-12352","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-liver-cancer","tag-chg-cancer-center","tag-child-pugh-score","tag-immunotherapy","tag-tace","tag-targeted-therapy","tag--tare","tag-906","tag-338","tag-97","tag-905","tag-liver-cancer","tag-260","tag-93","tag-903","tag-90"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts\/12352","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/comments?post=12352"}],"version-history":[{"count":0,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts\/12352\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/media\/12361"}],"wp:attachment":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/media?parent=12352"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/categories?post=12352"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/tags?post=12352"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}