{"id":12429,"date":"2025-01-25T11:00:08","date_gmt":"2025-01-25T04:00:08","guid":{"rendered":"https:\/\/chgcancercenter.com\/?p=12429"},"modified":"2025-01-29T01:15:27","modified_gmt":"2025-01-28T18:15:27","slug":"atezolizumab-bevacizumab-liver-cancer-treatment","status":"publish","type":"post","link":"https:\/\/chgcancercenter.com\/en\/atezolizumab-bevacizumab-liver-cancer-treatment\/","title":{"rendered":"Atezo+Bev \u0e40\u0e1e\u0e34\u0e48\u0e21\u0e42\u0e2d\u0e01\u0e32\u0e2a\u0e23\u0e2d\u0e14\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e15\u0e31\u0e1a\u0e23\u0e30\u0e22\u0e30\u0e25\u0e38\u0e01\u0e25\u0e32\u0e21\ufeff"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"12429\" class=\"elementor elementor-12429\">\n\t\t\t\t<div class=\"elementor-element elementor-element-53eb7dc6 e-flex e-con-boxed e-con e-parent\" data-id=\"53eb7dc6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1995faba elementor-widget elementor-widget-text-editor\" data-id=\"1995faba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h1><span style=\"font-size: 24pt;\"><strong>Atezolizumab (Atezo) and Bevacizumab (Bev): A Breakthrough Treatment for Advanced Liver Cancer (HCC)<\/strong><\/span><\/h1><p class=\"translation-block\">Atezolizumab (Atezo) combined with Bevacizumab (Bev) is a widely accepted treatment for advanced Hepatocellular Carcinoma (HCC) due to its superior outcomes compared to targeted therapy alone, such as Sorafenib.<\/p><h2><span style=\"font-size: 18pt;\"><b>Mechanism of Action of Atezolizumab and Bevacizumab<\/b><\/span><\/h2><h3><span style=\"font-size: 14pt;\"><b>1. Atezolizumab (Atezo)<\/b><\/span><\/h3><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">An Immune Checkpoint Inhibitor.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Inhibits PD-L1 (Programmed Death-Ligand 1), a protein cancer cells use to evade immune attacks.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blocking PD-L1 allows the immune system to recognize and destroy cancer cells more effectively.<\/span><\/li><\/ul><h3><span style=\"font-size: 14pt;\"><b>2. Bevacizumab (Bev)<\/b><\/span><\/h3><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">An Anti-angiogenic Therapy.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Inhibits VEGF (Vascular Endothelial Growth Factor), a protein that stimulates new blood vessel formation to feed tumors.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blocking VEGF cuts off the tumor\u2019s oxygen and nutrient supply, slowing its growth.<\/span><\/li><\/ul><h2><span style=\"font-size: 18pt;\"><b>Synergistic Action of Atezo and Bev<\/b><\/span><\/h2><p><span style=\"font-weight: 400;\">The use of Atezolizumab together with Bevacizumab enhances each other's effects as follows:<\/span><\/p><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Bevacizumab reduces blood supply to the tumor, depriving it of nutrients.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Atezolizumab boosts the immune system to target and kill cancer cells.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bevacizumab also improves immune cell infiltration into the tumor, enhancing Atezolizumab's efficacy.<\/span><\/li><\/ul><h2><span style=\"font-size: 18pt;\"><b>Indications for Atezo\/Bev in Liver Cancer Treatment<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Advanced or metastatic HCC patients.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Patients unsuitable for localized treatments (e.g., surgery or TACE).<\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Patients with good liver function (Child-Pugh A) and no history of gastrointestinal bleeding.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-03fc15b e-flex e-con-boxed e-con e-parent\" data-id=\"03fc15b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-36c3cc6 elementor-widget elementor-widget-text-editor\" data-id=\"36c3cc6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><span style=\"color: #000000; font-size: 18pt;\"><b>Effectiveness of Atezo\/Bev<\/b><\/span><\/h2><ul><li class=\"translation-block\">Patients receiving Atezolizumab + Bevacizumab had a better survival rate than those receiving Sorafenib (traditional Targeted Therapy).<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Overall Survival (OS): Significantly increased<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Progression-Free Survival (PFS): The length of time the disease does not progress.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Quality of Life: The patient's quality of life is improved compared to traditional treatment.<\/li><\/ul><h2><span style=\"color: #000000; font-size: 18pt;\"><b>Possible Side Effects<\/b><\/span><\/h2><h3><span style=\"color: #000000; font-size: 14pt;\"><b>Atezolizumab<\/b><\/span><\/h3><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; color: #000000;\">Fatigue<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; color: #000000;\">Skin rash or inflammation<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; color: #000000;\">Diarrhea<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; color: #000000;\">Immune-related adverse events (e.g., thyroid issues, pneumonitis, hepatitis)<\/span><\/li><\/ul><h3><span style=\"color: #000000; font-size: 14pt;\"><b>Bevacizumab<\/b><\/span><\/h3><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; color: #000000;\">High blood pressure<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; color: #000000;\">Gastrointestinal bleeding<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; color: #000000;\">Slow wound healing<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; color: #000000;\">Proteinuria (high protein in urine)<\/span><\/li><\/ul><p class=\"translation-block\">Note: Physicians must carefully assess patient suitability for combined treatment.<\/p><h2><span style=\"color: #000000; font-size: 18pt;\"><b>Limitations of Atezo\/Bev<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; color: #000000;\">Not suitable for patients with gastrointestinal bleeding or esophageal varices without proper management.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Not recommended for severe liver dysfunction (Child-Pugh B or C).<\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400; color: #000000;\">Requires close monitoring of liver function and blood pressure.<\/span><\/li><\/ul><p class=\"translation-block\">Combining Atezolizumab and Bevacizumab offers a powerful and effective treatment for advanced liver cancer by enhancing immune response and inhibiting tumor blood supply. This combination significantly improves survival and quality of life compared to targeted therapy alone.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c0896a9 e-flex e-con-boxed e-con e-parent\" data-id=\"c0896a9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7d86375 elementor-widget elementor-widget-video\" data-id=\"7d86375\" data-element_type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=tYxxR4VCDOU&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a93b92e e-flex e-con-boxed e-con e-parent\" data-id=\"a93b92e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-93ea625 elementor-widget elementor-widget-image\" data-id=\"93ea625\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"480\" src=\"https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/Atezolizumab-Atezo-and-Bevacizumab-Bev_-A-Breakthrough-Treatment-for-Advanced-Liver-Cancer-HCC2.jpg\" class=\"attachment-large size-large wp-image-12438\" alt=\"\u0e20\u0e32\u0e1e\u0e1b\u0e23\u0e30\u0e01\u0e2d\u0e1a\u0e17\u0e32\u0e07\u0e01\u0e32\u0e23\u0e41\u0e1e\u0e17\u0e22\u0e4c\u0e41\u0e2a\u0e14\u0e07\u0e01\u0e32\u0e23\u0e01\u0e23\u0e30\u0e17\u0e33\u0e23\u0e48\u0e27\u0e21\u0e01\u0e31\u0e19\u0e02\u0e2d\u0e07 Atezolizumab \u0e41\u0e25\u0e30 Bevacizumab \u0e43\u0e19\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e15\u0e31\u0e1a\u0e23\u0e30\u0e22\u0e30\u0e25\u0e38\u0e01\u0e25\u0e32\u0e21 Atezolizumab \u0e0a\u0e48\u0e27\u0e22\u0e40\u0e1e\u0e34\u0e48\u0e21\u0e01\u0e32\u0e23\u0e15\u0e2d\u0e1a\u0e2a\u0e19\u0e2d\u0e07\u0e02\u0e2d\u0e07\u0e23\u0e30\u0e1a\u0e1a\u0e20\u0e39\u0e21\u0e34\u0e04\u0e38\u0e49\u0e21\u0e01\u0e31\u0e19 \u0e43\u0e19\u0e02\u0e13\u0e30\u0e17\u0e35\u0e48 Bevacizumab \u0e02\u0e31\u0e14\u0e02\u0e27\u0e32\u0e07\u0e01\u0e32\u0e23\u0e2a\u0e23\u0e49\u0e32\u0e07\u0e2b\u0e25\u0e2d\u0e14\u0e40\u0e25\u0e37\u0e2d\u0e14\u0e43\u0e2b\u0e21\u0e48\u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e17\u0e33\u0e43\u0e2b\u0e49\u0e40\u0e19\u0e37\u0e49\u0e2d\u0e07\u0e2d\u0e01\u0e2d\u0e14\u0e2d\u0e32\u0e2b\u0e32\u0e23\" srcset=\"https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/Atezolizumab-Atezo-and-Bevacizumab-Bev_-A-Breakthrough-Treatment-for-Advanced-Liver-Cancer-HCC2.jpg 800w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/Atezolizumab-Atezo-and-Bevacizumab-Bev_-A-Breakthrough-Treatment-for-Advanced-Liver-Cancer-HCC2-300x225.jpg 300w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/Atezolizumab-Atezo-and-Bevacizumab-Bev_-A-Breakthrough-Treatment-for-Advanced-Liver-Cancer-HCC2-768x576.jpg 768w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/Atezolizumab-Atezo-and-Bevacizumab-Bev_-A-Breakthrough-Treatment-for-Advanced-Liver-Cancer-HCC2-16x12.jpg 16w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/Atezolizumab-Atezo-and-Bevacizumab-Bev_-A-Breakthrough-Treatment-for-Advanced-Liver-Cancer-HCC2-600x450.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-32e8f1d e-flex e-con-boxed e-con e-parent\" data-id=\"32e8f1d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18e9011 elementor-widget elementor-widget-ct_text_editor\" data-id=\"18e9011\" data-element_type=\"widget\" data-widget_type=\"ct_text_editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"ct_text_editor-18e9011\" class=\"ct-text-editor wow fadeInUp\" data-wow-delay=\"ms\">\n\t<div class=\"ct-item--inner\">\n\t\t<div class=\"ct-inline-css\"  data-css=\"\t        \t\t\t\">\n\n\t    <\/div>\n\t\t<div class=\"ct-text-editor elementor-clearfix\">\n\t\t\t<p class=\"translation-block\">For inquiry, please call <a href=\"tel:0638166058\" target=\"_self\">+66638166058<\/a><\/p>\t\t\n\t\t<\/div>\n\t<\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc4a6ee e-flex e-con-boxed e-con e-child\" data-id=\"cc4a6ee\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c0616b5 e-con-full e-flex e-con e-child\" data-id=\"c0616b5\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e7c50bd elementor-widget elementor-widget-text-editor\" data-id=\"e7c50bd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-family: lineseedsansth;\">Request consultation for treatment plan<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9058c76 e-con-full e-flex e-con e-child\" data-id=\"9058c76\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d1e4874 elementor-widget elementor-widget-text-editor\" data-id=\"d1e4874\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/lin.ee\/sx9JJLJ\"><img decoding=\"async\" class=\"\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/th.png\" alt=\"\u0e40\u0e1e\u0e34\u0e48\u0e21\u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e19\" width=\"115\" height=\"36\" border=\"0\" \/><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-549157e e-flex e-con-boxed e-con e-child\" data-id=\"549157e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Atezolizumab \u0e23\u0e48\u0e27\u0e21\u0e01\u0e31\u0e1a Bevacizumab \u0e17\u0e32\u0e07\u0e40\u0e25\u0e37\u0e2d\u0e01\u0e43\u0e2b\u0e21\u0e48\u0e43\u0e19\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e15\u0e31\u0e1a\u0e23\u0e30\u0e22\u0e30\u0e25\u0e38\u0e01\u0e25\u0e32\u0e21 \u0e40\u0e1e\u0e34\u0e48\u0e21\u0e1b\u0e23\u0e30\u0e2a\u0e34\u0e17\u0e18\u0e34\u0e20\u0e32\u0e1e\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e41\u0e25\u0e30\u0e22\u0e37\u0e14\u0e2d\u0e32\u0e22\u0e38\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22\u0e44\u0e14\u0e49\u0e14\u0e35\u0e01\u0e27\u0e48\u0e32\u0e40\u0e14\u0e34\u0e21<\/p>","protected":false},"author":2,"featured_media":12442,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[64],"tags":[919,916,917,62,912,902,920,338,97,918,921,896,260,93,90],"class_list":["post-12429","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-liver-cancer","tag-anti-angiogenic-therapy","tag-atezolizumab","tag-bevacizumab","tag-chg-cancer-center","tag-hepatocellular-carcinoma-hcc","tag-immunotherapy","tag-920","tag-338","tag-97","tag-918","tag-921","tag-896","tag-260","tag-93","tag-90"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts\/12429","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/comments?post=12429"}],"version-history":[{"count":0,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts\/12429\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/media\/12442"}],"wp:attachment":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/media?parent=12429"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/categories?post=12429"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/tags?post=12429"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}