{"id":12469,"date":"2025-01-25T13:00:30","date_gmt":"2025-01-25T06:00:30","guid":{"rendered":"https:\/\/chgcancercenter.com\/?p=12469"},"modified":"2025-01-29T08:03:41","modified_gmt":"2025-01-29T01:03:41","slug":"msi-h-locally-advanced-rectal-cancer-treatment","status":"publish","type":"post","link":"https:\/\/chgcancercenter.com\/en\/msi-h-locally-advanced-rectal-cancer-treatment\/","title":{"rendered":"New Hope Treating MSI-H Locally Advanced Rectal Cancer"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"12469\" class=\"elementor elementor-12469\">\n\t\t\t\t<div class=\"elementor-element elementor-element-53eb7dc6 e-flex e-con-boxed e-con e-parent\" data-id=\"53eb7dc6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1995faba elementor-widget elementor-widget-text-editor\" data-id=\"1995faba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h1><span style=\"font-size: 24pt;\"><strong>New Hope Treating MSI-H Locally Advanced Rectal Cancer<\/strong><\/span><\/h1><p class=\"translation-block\">MSI-H Locally Advanced Rectal Cancer refers to rectal cancer that is locally advanced and exhibits Microsatellite Instability-High (MSI-H), a genetic abnormality caused by defective Mismatch Repair Genes (MMR). This instability leads to abnormal cancer cell growth and division.<\/p><h2><span style=\"font-size: 18pt;\"><b>Significance of MSI-H in Rectal Cancer<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">MSI-H is commonly found in patients with a family history of cancer, such as Lynch Syndrome.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Patients with MSI-H often respond better to Immunotherapy compared to conventional treatments.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">This cancer type has numerous mutations, making it easier for the immune system to detect and destroy cancer cells.<\/span><\/li><\/ul><h2><span style=\"font-size: 18pt;\"><b>Treatment Options for MSI-H Locally Advanced Rectal Cancer<\/b><\/span><\/h2><h3><span style=\"font-size: 14pt;\"><b>1. Immunotherapy<\/b><\/span><\/h3><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A highly effective treatment for MSI-H cancer using Immune Checkpoint Inhibitors, such as:<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\">Medicines in the group Immune Checkpoint Inhibitors<ul><li style=\"font-weight: 400;\" aria-level=\"1\">Pembrolizumab (Keytruda) is a commonly used drug for this treatment.<\/li><li style=\"font-weight: 400;\" aria-level=\"2\">Nivolumab (Opdivo)<\/li><li style=\"font-weight: 400;\" aria-level=\"2\">Dostarlimab (Jemperli)<\/li><\/ul><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">These drugs can significantly shrink tumors and, in some cases, eliminate the need for surgery.<\/span><\/li><\/ul><h3><span style=\"font-size: 14pt;\"><b>2. Standard Treatment<\/b><\/span><\/h3><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Neoadjuvant Chemoradiotherapy: Radiation combined with chemotherapy to shrink the tumor before surgery.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/chgcancercenter.com\/en\/cancers-treatable-with-surgery-alone\/\">Surgery<\/a><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Total Mesorectal Excision (TME): Removal of the rectum and surrounding tissue.<\/li><li style=\"font-weight: 400;\" aria-level=\"2\" class=\"translation-block\">Local Excision: For small, non-invasive tumors.<\/li><\/ul><\/li><\/ul><h3><span style=\"font-size: 14pt;\"><b>3. Non-operative Management (Watch and Wait)<\/b><\/span><\/h3><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Patients who respond well to Immunotherapy may follow a \"Watch and Wait\" strategy, closely monitoring the tumor without surgery.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-03fc15b e-flex e-con-boxed e-con e-parent\" data-id=\"03fc15b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-36c3cc6 elementor-widget elementor-widget-text-editor\" data-id=\"36c3cc6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><span style=\"color: #000000; font-size: 18pt;\"><b>Advantages of Immunotherapy in MSI-H Rectal Cancer<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Tumor Reduction or Elimination: Potentially avoiding surgery.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Fewer Side Effects: Compared to chemotherapy and radiation (e.g., diarrhea, inflammation).<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Lower Recurrence Risk: Enhancing immune response to destroy remaining cancer cells.<\/li><\/ul><p class=\"translation-block\">MSI-H Locally Advanced Rectal Cancer responds exceptionally well to Immunotherapy, especially with Immune Checkpoint Inhibitors. This treatment approach can reduce tumor size and, in some cases, eliminate the need for surgery, offering patients a promising path to recovery.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c0896a9 e-flex e-con-boxed e-con e-parent\" data-id=\"c0896a9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7d86375 elementor-widget elementor-widget-video\" data-id=\"7d86375\" data-element_type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=bvACr3zPInk&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a93b92e e-flex e-con-boxed e-con e-parent\" data-id=\"a93b92e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-93ea625 elementor-widget elementor-widget-image\" data-id=\"93ea625\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"480\" src=\"https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/New-Hope-Treating-MSI-H-Locally-Advanced-Rectal-Cancer2.jpg\" class=\"attachment-large size-large wp-image-12478\" alt=\"\u0e20\u0e32\u0e1e\u0e1b\u0e23\u0e30\u0e01\u0e2d\u0e1a\u0e17\u0e32\u0e07\u0e01\u0e32\u0e23\u0e41\u0e1e\u0e17\u0e22\u0e4c\u0e02\u0e2d\u0e07\u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e17\u0e27\u0e32\u0e23\u0e2b\u0e19\u0e31\u0e01\u0e02\u0e31\u0e49\u0e19\u0e2a\u0e39\u0e07\u0e40\u0e09\u0e1e\u0e32\u0e30\u0e17\u0e35\u0e48\u0e02\u0e2d\u0e07 MSI-H \u0e0b\u0e36\u0e48\u0e07\u0e41\u0e2a\u0e14\u0e07\u0e2a\u0e32\u0e23\u0e22\u0e31\u0e1a\u0e22\u0e31\u0e49\u0e07\u0e08\u0e38\u0e14\u0e15\u0e23\u0e27\u0e08\u0e20\u0e39\u0e21\u0e34\u0e04\u0e38\u0e49\u0e21\u0e01\u0e31\u0e19 \u0e40\u0e0a\u0e48\u0e19 Pembrolizumab \u0e41\u0e25\u0e30 Nivolumab \u0e17\u0e35\u0e48\u0e21\u0e38\u0e48\u0e07\u0e40\u0e1b\u0e49\u0e32\u0e44\u0e1b\u0e17\u0e35\u0e48\u0e40\u0e0b\u0e25\u0e25\u0e4c\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07 \u0e42\u0e14\u0e22\u0e40\u0e19\u0e49\u0e19\u0e17\u0e35\u0e48\u0e17\u0e27\u0e32\u0e23\u0e2b\u0e19\u0e31\u0e01\" srcset=\"https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/New-Hope-Treating-MSI-H-Locally-Advanced-Rectal-Cancer2.jpg 800w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/New-Hope-Treating-MSI-H-Locally-Advanced-Rectal-Cancer2-300x225.jpg 300w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/New-Hope-Treating-MSI-H-Locally-Advanced-Rectal-Cancer2-768x576.jpg 768w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/New-Hope-Treating-MSI-H-Locally-Advanced-Rectal-Cancer2-16x12.jpg 16w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/New-Hope-Treating-MSI-H-Locally-Advanced-Rectal-Cancer2-600x450.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-32e8f1d e-flex e-con-boxed e-con e-parent\" data-id=\"32e8f1d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18e9011 elementor-widget elementor-widget-ct_text_editor\" data-id=\"18e9011\" data-element_type=\"widget\" data-widget_type=\"ct_text_editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"ct_text_editor-18e9011\" class=\"ct-text-editor wow fadeInUp\" data-wow-delay=\"ms\">\n\t<div class=\"ct-item--inner\">\n\t\t<div class=\"ct-inline-css\"  data-css=\"\t        \t\t\t\">\n\n\t    <\/div>\n\t\t<div class=\"ct-text-editor elementor-clearfix\">\n\t\t\t<p class=\"translation-block\">For inquiry, please call <a href=\"tel:0638166058\" target=\"_self\">+66638166058<\/a><\/p>\t\t\n\t\t<\/div>\n\t<\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc4a6ee e-flex e-con-boxed e-con e-child\" data-id=\"cc4a6ee\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c0616b5 e-con-full e-flex e-con e-child\" data-id=\"c0616b5\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e7c50bd elementor-widget elementor-widget-text-editor\" data-id=\"e7c50bd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-family: lineseedsansth;\">Request consultation for treatment plan<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9058c76 e-con-full e-flex e-con e-child\" data-id=\"9058c76\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d1e4874 elementor-widget elementor-widget-text-editor\" data-id=\"d1e4874\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/lin.ee\/sx9JJLJ\"><img decoding=\"async\" class=\"\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/th.png\" alt=\"\u0e40\u0e1e\u0e34\u0e48\u0e21\u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e19\" width=\"115\" height=\"36\" border=\"0\" \/><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-549157e e-flex e-con-boxed e-con e-child\" data-id=\"549157e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u0e40\u0e08\u0e32\u0e30\u0e25\u0e36\u0e01\u0e41\u0e19\u0e27\u0e17\u0e32\u0e07\u0e23\u0e31\u0e01\u0e29\u0e32\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e25\u0e33\u0e44\u0e2a\u0e49\u0e15\u0e23\u0e07 MSI-H \u0e14\u0e49\u0e27\u0e22\u0e20\u0e39\u0e21\u0e34\u0e04\u0e38\u0e49\u0e21\u0e01\u0e31\u0e19\u0e1a\u0e33\u0e1a\u0e31\u0e14 \u0e25\u0e14\u0e02\u0e19\u0e32\u0e14\u0e01\u0e49\u0e2d\u0e19\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e41\u0e25\u0e30\u0e25\u0e14\u0e42\u0e2d\u0e01\u0e32\u0e2a\u0e01\u0e25\u0e31\u0e1a\u0e21\u0e32\u0e40\u0e1b\u0e47\u0e19\u0e0b\u0e49\u0e33 \u0e40\u0e1e\u0e34\u0e48\u0e21\u0e42\u0e2d\u0e01\u0e32\u0e2a\u0e2b\u0e32\u0e22\u0e02\u0e32\u0e14\u0e42\u0e14\u0e22\u0e44\u0e21\u0e48\u0e15\u0e49\u0e2d\u0e07\u0e1c\u0e48\u0e32\u0e15\u0e31\u0e14<\/p>","protected":false},"author":2,"featured_media":12482,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[65],"tags":[62,937,934,932,938,936,935,939,924,97,536,933,260,93,90],"class_list":["post-12469","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colon-cancer","tag-chg-cancer-center","tag-dostarlimab","tag-immune-checkpoint-inhibitors","tag-msi-h-rectal-cancer","tag-neoadjuvant-chemoradiotherapy","tag-nivolumab","tag-pembrolizumab","tag-watch-and-wait-strategy","tag-924","tag-97","tag-536","tag--msi-h","tag-260","tag-93","tag-90"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts\/12469","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/comments?post=12469"}],"version-history":[{"count":0,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts\/12469\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/media\/12482"}],"wp:attachment":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/media?parent=12469"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/categories?post=12469"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/tags?post=12469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}