{"id":12514,"date":"2025-01-27T10:00:44","date_gmt":"2025-01-27T03:00:44","guid":{"rendered":"https:\/\/chgcancercenter.com\/?p=12514"},"modified":"2025-01-29T09:53:43","modified_gmt":"2025-01-29T02:53:43","slug":"neoadjuvant-therapy-tumor-reduction-before-surgery","status":"publish","type":"post","link":"https:\/\/chgcancercenter.com\/en\/neoadjuvant-therapy-tumor-reduction-before-surgery\/","title":{"rendered":"Neoadjuvant Therapy: Shrinking Tumors Before Surgery"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"12514\" class=\"elementor elementor-12514\">\n\t\t\t\t<div class=\"elementor-element elementor-element-53eb7dc6 e-flex e-con-boxed e-con e-parent\" data-id=\"53eb7dc6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1995faba elementor-widget elementor-widget-text-editor\" data-id=\"1995faba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h1><span style=\"font-size: 24pt;\"><strong>Neoadjuvant Therapy: Shrinking Tumors Before Surgery<\/strong><\/span><\/h1><p class=\"translation-block\">Neoadjuvant Therapy refers to treatment administered before surgery to shrink tumors and increase the success of surgical removal, especially for locally advanced colorectal cancer. This approach helps lower the risk of recurrence and prevents cancer from spreading.<\/p><h2><span style=\"font-size: 18pt;\"><b>Objectives of Neoadjuvant Therapy<\/b><\/span><\/h2><ol><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Shrink tumors to ease surgical removal and reduce surgical risks.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Lower recurrence risk by eliminating microscopic cancer cells.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Increase the chance of curative surgery, especially for hard-to-reach tumors.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Preserve sphincter function, reducing the need for a permanent colostomy in rectal cancer near the anus.<\/li><\/ol><h2><span style=\"font-size: 18pt;\"><b>Types of Neoadjuvant Therapy<\/b><\/span><\/h2><h3><span style=\"font-size: 14pt;\"><b>1. Chemoradiotherapy<\/b><\/span><\/h3><ul><li style=\"font-weight: 400;\" aria-level=\"1\">Standard for Stage II-III rectal cancer.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Combines radiation therapy with chemotherapy drugs like 5-Fluorouracil (5-FU) or Capecitabine.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduces tumor size and limits cancer spread.<\/span><\/li><\/ul><h3><span style=\"font-size: 14pt;\"><b>2. Neoadjuvant Chemotherapy<\/b><\/span><\/h3><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Common for non-metastatic colon cancer.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Drug regimens include FOLFOX (5-FU, Leucovorin, Oxaliplatin) or CAPOX (Capecitabine, Oxaliplatin).<\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Shrinks tumors and targets potential metastases.<\/span><\/li><\/ul><h3><span style=\"font-size: 14pt;\"><b>3. Targeted Therapy<\/b><\/span><\/h3><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Used alongside chemotherapy for genetic mutations (e.g., RAS, BRAF).<\/li><li style=\"font-weight: 400;\" aria-level=\"1\">Drugs like Bevacizumab (Avastin) and Cetuximab are effective for RAS wild-type cancers.<\/li><\/ul><h3><span style=\"font-size: 14pt;\"><b>4. Immunotherapy<\/b><\/span><\/h3><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">For cancers with MSI-H (Microsatellite Instability-High) or dMMR (Mismatch Repair Deficiency).<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Pembrolizumab (Keytruda) and Nivolumab (Opdivo) boost immune responses to attack cancer cells.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Helps stimulate the immune system to destroy cancer cells.<\/span><\/li><\/ul><h2><span style=\"font-size: 18pt;\"><b>Treatment Options<\/b><\/span><\/h2><ol><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Begin with Neoadjuvant Therapy to shrink the tumor.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Evaluate response with MRI or CT scans.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Perform surgery, such as Total Mesorectal Excision (TME) for rectal cancer.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Continue with Adjuvant Therapy if recurrence risk persists.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-03fc15b e-flex e-con-boxed e-con e-parent\" data-id=\"03fc15b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-36c3cc6 elementor-widget elementor-widget-text-editor\" data-id=\"36c3cc6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><span style=\"color: #000000; font-size: 18pt;\"><b>Advantages of Neoadjuvant Therapy<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Tumor reduction: Makes surgery easier and more effective.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Lower recurrence risk: Especially in rectal cancer.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Preserves sphincter function: Reduces the need for a stoma.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Enhanced treatment efficacy: Prevents cancer spread.<\/li><\/ul><h2><span style=\"color: #000000; font-size: 18pt;\"><b>Limitations of Neoadjuvant Therapy<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Side effects: Fatigue, diarrhea, mouth sores from chemo or radiation.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Non-responsiveness: Some cancers are resistant to treatment.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Longer treatment duration: Delays surgery.<\/li><\/ul><p class=\"translation-block\">Neoadjuvant Therapy is an effective strategy for managing locally advanced colorectal cancer. It improves surgical outcomes and lowers recurrence risk, especially when combining chemoradiotherapy and immunotherapy for appropriate cases.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a93b92e e-flex e-con-boxed e-con e-parent\" data-id=\"a93b92e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-93ea625 elementor-widget elementor-widget-image\" data-id=\"93ea625\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"480\" src=\"https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/Neoadjuvant-Therapy_-Shrinking-Tumors-Before-Surgery2.jpg\" class=\"attachment-large size-large wp-image-12526\" alt=\"\u0e20\u0e32\u0e1e\u0e1b\u0e23\u0e30\u0e01\u0e2d\u0e1a\u0e17\u0e32\u0e07\u0e01\u0e32\u0e23\u0e41\u0e1e\u0e17\u0e22\u0e4c\u0e41\u0e2a\u0e14\u0e07\u0e01\u0e32\u0e23\u0e1a\u0e33\u0e1a\u0e31\u0e14\u0e41\u0e1a\u0e1a\u0e19\u0e35\u0e42\u0e2d\u0e41\u0e2d\u0e14\u0e08\u0e39\u0e41\u0e27\u0e19\u0e17\u0e4c\u0e2a\u0e33\u0e2b\u0e23\u0e31\u0e1a\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e25\u0e33\u0e44\u0e2a\u0e49\u0e43\u0e2b\u0e0d\u0e48 \u0e20\u0e32\u0e1e\u0e40\u0e19\u0e49\u0e19\u0e01\u0e23\u0e30\u0e1a\u0e27\u0e19\u0e01\u0e32\u0e23\u0e2b\u0e14\u0e15\u0e31\u0e27\u0e02\u0e2d\u0e07\u0e40\u0e19\u0e37\u0e49\u0e2d\u0e07\u0e2d\u0e01\u0e42\u0e14\u0e22\u0e43\u0e0a\u0e49\u0e40\u0e04\u0e21\u0e35\u0e1a\u0e33\u0e1a\u0e31\u0e14 \u0e23\u0e31\u0e07\u0e2a\u0e35\u0e1a\u0e33\u0e1a\u0e31\u0e14 \u0e01\u0e32\u0e23\u0e1a\u0e33\u0e1a\u0e31\u0e14\u0e41\u0e1a\u0e1a\u0e01\u0e33\u0e2b\u0e19\u0e14\u0e40\u0e1b\u0e49\u0e32\u0e2b\u0e21\u0e32\u0e22 \u0e41\u0e25\u0e30\u0e20\u0e39\u0e21\u0e34\u0e04\u0e38\u0e49\u0e21\u0e01\u0e31\u0e19\u0e1a\u0e33\u0e1a\u0e31\u0e14\u0e01\u0e48\u0e2d\u0e19\u0e01\u0e32\u0e23\u0e1c\u0e48\u0e32\u0e15\u0e31\u0e14\" srcset=\"https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/Neoadjuvant-Therapy_-Shrinking-Tumors-Before-Surgery2.jpg 800w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/Neoadjuvant-Therapy_-Shrinking-Tumors-Before-Surgery2-300x225.jpg 300w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/Neoadjuvant-Therapy_-Shrinking-Tumors-Before-Surgery2-768x576.jpg 768w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/Neoadjuvant-Therapy_-Shrinking-Tumors-Before-Surgery2-16x12.jpg 16w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/01\/Neoadjuvant-Therapy_-Shrinking-Tumors-Before-Surgery2-600x450.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-32e8f1d e-flex e-con-boxed e-con e-parent\" data-id=\"32e8f1d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18e9011 elementor-widget elementor-widget-ct_text_editor\" data-id=\"18e9011\" data-element_type=\"widget\" data-widget_type=\"ct_text_editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"ct_text_editor-18e9011\" class=\"ct-text-editor wow fadeInUp\" data-wow-delay=\"ms\">\n\t<div class=\"ct-item--inner\">\n\t\t<div class=\"ct-inline-css\"  data-css=\"\t        \t\t\t\">\n\n\t    <\/div>\n\t\t<div class=\"ct-text-editor elementor-clearfix\">\n\t\t\t<p class=\"translation-block\">For inquiry, please call <a href=\"tel:0638166058\" target=\"_self\">+66638166058<\/a><\/p>\t\t\n\t\t<\/div>\n\t<\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc4a6ee e-flex e-con-boxed e-con e-child\" data-id=\"cc4a6ee\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c0616b5 e-con-full e-flex e-con e-child\" data-id=\"c0616b5\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e7c50bd elementor-widget elementor-widget-text-editor\" data-id=\"e7c50bd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-family: lineseedsansth;\">Request consultation for treatment plan<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9058c76 e-con-full e-flex e-con e-child\" data-id=\"9058c76\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d1e4874 elementor-widget elementor-widget-text-editor\" data-id=\"d1e4874\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/lin.ee\/sx9JJLJ\"><img decoding=\"async\" class=\"\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/th.png\" alt=\"\u0e40\u0e1e\u0e34\u0e48\u0e21\u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e19\" width=\"115\" height=\"36\" border=\"0\" \/><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-549157e e-flex e-con-boxed e-con e-child\" data-id=\"549157e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u0e23\u0e39\u0e49\u0e08\u0e31\u0e01 Neoadjuvant Therapy \u0e41\u0e19\u0e27\u0e17\u0e32\u0e07\u0e23\u0e31\u0e01\u0e29\u0e32\u0e01\u0e48\u0e2d\u0e19\u0e1c\u0e48\u0e32\u0e15\u0e31\u0e14 \u0e0a\u0e48\u0e27\u0e22\u0e25\u0e14\u0e02\u0e19\u0e32\u0e14\u0e01\u0e49\u0e2d\u0e19\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07 \u0e40\u0e1e\u0e34\u0e48\u0e21\u0e42\u0e2d\u0e01\u0e32\u0e2a\u0e01\u0e32\u0e23\u0e1c\u0e48\u0e32\u0e15\u0e31\u0e14\u0e2a\u0e33\u0e40\u0e23\u0e47\u0e08 \u0e41\u0e25\u0e30\u0e25\u0e14\u0e04\u0e27\u0e32\u0e21\u0e40\u0e2a\u0e35\u0e48\u0e22\u0e07\u0e01\u0e32\u0e23\u0e01\u0e25\u0e31\u0e1a\u0e21\u0e32\u0e40\u0e1b\u0e47\u0e19\u0e0b\u0e49\u0e33<\/p>","protected":false},"author":2,"featured_media":12530,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[65],"tags":[950,62,948,384,949,97,181,127,922,156,260,951,93,115,90],"class_list":["post-12514","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colon-cancer","tag-chemoradiotherapy","tag-chg-cancer-center","tag-neoadjuvant-therapy","tag-targeted-therapy","tag-949","tag-97","tag-181","tag-127","tag-922","tag-156","tag-260","tag-951","tag-93","tag-115","tag-90"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts\/12514","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/comments?post=12514"}],"version-history":[{"count":0,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts\/12514\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/media\/12530"}],"wp:attachment":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/media?parent=12514"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/categories?post=12514"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/tags?post=12514"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}