{"id":13343,"date":"2025-04-30T09:30:07","date_gmt":"2025-04-30T02:30:07","guid":{"rendered":"https:\/\/chgcancercenter.com\/?p=13343"},"modified":"2025-05-02T04:12:38","modified_gmt":"2025-05-01T21:12:38","slug":"how-cancer-escapes-immune-system","status":"publish","type":"post","link":"https:\/\/chgcancercenter.com\/en\/how-cancer-escapes-immune-system\/","title":{"rendered":"\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e2b\u0e19\u0e35\u0e20\u0e39\u0e21\u0e34\u0e04\u0e38\u0e49\u0e21\u0e01\u0e31\u0e19\u0e44\u0e14\u0e49\u0e22\u0e31\u0e07\u0e44\u0e07? \ufeff"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"13343\" class=\"elementor elementor-13343\">\n\t\t\t\t<div class=\"elementor-element elementor-element-53eb7dc6 e-flex e-con-boxed e-con e-parent\" data-id=\"53eb7dc6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1995faba elementor-widget elementor-widget-text-editor\" data-id=\"1995faba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h1><span style=\"font-size: 24pt;\"><strong>How Cancer Escapes the Immune System <\/strong><\/span><\/h1><p class=\"translation-block\">One of the most frightening capabilities of cancer cells is their ability to \"evade the body's immune system.\" Normally, white blood cells like CD8+ T cells and NK cells should recognize and destroy cancer cells. However, cancer develops several strategies to survive and grow. Here\u2019s how cancer escapes immunity:<\/p><h2><span style=\"font-size: 18pt;\"><b>1. Recruiting Immunosuppressive White Blood Cells<\/b><\/span><\/h2><p><span style=\"font-weight: 400;\">Cancer can attract immune cells that suppress immunity to work on its side, such as:<\/span><\/p><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Treg (Regulatory T cells): Secretes IL-10 to strongly suppress immune responses.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">MDSC (Myeloid-Derived Suppressor Cells): Releases various inhibitory substances and supports cancer growth.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">M2d Macrophages: Transitioned macrophages that promote angiogenesis and tumor-friendly environments.<\/li><\/ul><h2><span style=\"font-size: 18pt;\"><b>2. Shutting Down Immune Cells via \u201cImmune Checkpoints\u201d<\/b><\/span><\/h2><p class=\"translation-block\">Cancer cells express proteins like PD-L1, binding to PD-1 on T cells and NK cells, effectively \"switching off\" their function.<\/p><h2><span style=\"font-size: 18pt;\"><b>3. Turning the Battlefield into an Acid Sea (Warburg Effect)<\/b><\/span><\/h2><p><span style=\"font-weight: 400;\">Cancer cells metabolize glucose into lactic acid (Warburg Effect), creating a highly acidic environment that:<\/span><\/p><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weakens immune cell function<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cuts off nutrients vital for immunity<\/span><\/li><\/ul><h2><span style=\"font-size: 18pt;\"><b>4. Hiding by Reducing MHC I Expression<\/b><\/span><\/h2><p class=\"translation-block\">Cancer cells can downregulate or alter MHC Class I proteins, making it harder for T cells to recognize them as threats.<\/p><h2><span style=\"font-size: 18pt;\"><b>5. Sending a \u201cDon\u2019t Eat Me\u201d Signal with CD47<\/b><\/span><\/h2><p class=\"translation-block\">When under attack, cancer cells express CD47 to signal macrophages: \"I'm part of the body, don't destroy me.\"<\/p><h2><span style=\"font-size: 18pt;\"><b>6. Transforming Monocytes into Allies<\/b><\/span><\/h2><p class=\"translation-block\">Cancer secretes Semaphorins to prevent monocytes from differentiating into cancer-killing macrophages and instead converts them into M2d macrophages, which support cancer growth.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-03fc15b e-flex e-con-boxed e-con e-parent\" data-id=\"03fc15b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-36c3cc6 elementor-widget elementor-widget-text-editor\" data-id=\"36c3cc6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><span style=\"color: #000000; font-size: 18pt;\"><b>Why Can Cancer Do This?<\/b><\/span><\/h2><p class=\"translation-block\">These immune escape mechanisms usually develop once the tumor has grown enough to establish its own microenvironment. In early stages, cancer cells are still vulnerable and easier for the immune system to eliminate.<\/p><p><span style=\"color: #000000; font-size: 18pt;\"><b>summarize<\/b><\/span><\/p><p><span style=\"font-weight: 400; color: #000000;\">Cancer cells aren't just abnormal cells; they are smart survivors using suppression, deception, and environmental manipulation to evade immune attacks.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a93b92e e-flex e-con-boxed e-con e-parent\" data-id=\"a93b92e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-93ea625 elementor-widget elementor-widget-image\" data-id=\"93ea625\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"360\" src=\"https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/04\/How-Cancer-Escapes-the-Immune-System1.jpg\" class=\"attachment-large size-large wp-image-13352\" alt=\"\u0e40\u0e0b\u0e25\u0e25\u0e4c\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e43\u0e0a\u0e49\u0e01\u0e25\u0e44\u0e01\u0e1b\u0e34\u0e14\u0e2a\u0e27\u0e34\u0e15\u0e0b\u0e4c\u0e20\u0e39\u0e21\u0e34\u0e04\u0e38\u0e49\u0e21\u0e01\u0e31\u0e19\u0e41\u0e25\u0e30\u0e1b\u0e49\u0e2d\u0e07\u0e01\u0e31\u0e19\u0e15\u0e31\u0e27\u0e08\u0e32\u0e01\u0e40\u0e21\u0e47\u0e14\u0e40\u0e25\u0e37\u0e2d\u0e14\u0e02\u0e32\u0e27\" srcset=\"https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/04\/How-Cancer-Escapes-the-Immune-System1.jpg 800w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/04\/How-Cancer-Escapes-the-Immune-System1-300x169.jpg 300w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/04\/How-Cancer-Escapes-the-Immune-System1-768x432.jpg 768w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/04\/How-Cancer-Escapes-the-Immune-System1-18x10.jpg 18w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/04\/How-Cancer-Escapes-the-Immune-System1-600x338.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-32e8f1d e-flex e-con-boxed e-con e-parent\" data-id=\"32e8f1d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18e9011 elementor-widget elementor-widget-ct_text_editor\" data-id=\"18e9011\" data-element_type=\"widget\" data-widget_type=\"ct_text_editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"ct_text_editor-18e9011\" class=\"ct-text-editor wow fadeInUp\" data-wow-delay=\"ms\">\n\t<div class=\"ct-item--inner\">\n\t\t<div class=\"ct-inline-css\"  data-css=\"\t        \t\t\t\">\n\n\t    <\/div>\n\t\t<div class=\"ct-text-editor elementor-clearfix\">\n\t\t\t<p class=\"translation-block\">For inquiry, please call <a href=\"tel:0638166058\" target=\"_self\">+66638166058<\/a><\/p>\t\t\n\t\t<\/div>\n\t<\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc4a6ee e-flex e-con-boxed e-con e-child\" data-id=\"cc4a6ee\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c0616b5 e-con-full e-flex e-con e-child\" data-id=\"c0616b5\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e7c50bd elementor-widget elementor-widget-text-editor\" data-id=\"e7c50bd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-family: lineseedsansth;\">Request consultation for treatment plan<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9058c76 e-con-full e-flex e-con e-child\" data-id=\"9058c76\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d1e4874 elementor-widget elementor-widget-text-editor\" data-id=\"d1e4874\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/lin.ee\/sx9JJLJ\"><img decoding=\"async\" class=\"\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/th.png\" alt=\"\u0e40\u0e1e\u0e34\u0e48\u0e21\u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e19\" width=\"115\" height=\"36\" border=\"0\" \/><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-549157e e-flex e-con-boxed e-con e-child\" data-id=\"549157e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e2b\u0e25\u0e1a\u0e40\u0e25\u0e35\u0e48\u0e22\u0e07\u0e20\u0e39\u0e21\u0e34\u0e04\u0e38\u0e49\u0e21\u0e01\u0e31\u0e19\u0e2d\u0e22\u0e48\u0e32\u0e07\u0e44\u0e23? \u0e2b\u0e19\u0e36\u0e48\u0e07\u0e43\u0e19\u0e04\u0e27\u0e32\u0e21\u0e2a\u0e32\u0e21\u0e32\u0e23\u0e16\u0e2d\u0e31\u0e19\u0e19\u0e48\u0e32\u0e01\u0e25\u0e31\u0e27\u0e02\u0e2d\u0e07\u0e40\u0e0b\u0e25\u0e25\u0e4c\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07 \u0e23\u0e39\u0e49\u0e17\u0e31\u0e19\u0e01\u0e25\u0e44\u0e01\u0e01\u0e32\u0e23\u0e1b\u0e34\u0e14\u0e2a\u0e27\u0e34\u0e15\u0e0b\u0e4c T cell, \u0e2a\u0e23\u0e49\u0e32\u0e07\u0e17\u0e30\u0e40\u0e25\u0e01\u0e23\u0e14, \u0e1e\u0e23\u0e32\u0e07\u0e15\u0e31\u0e27 \u0e41\u0e25\u0e30\u0e14\u0e36\u0e07\u0e40\u0e21\u0e47\u0e14\u0e40\u0e25\u0e37\u0e2d\u0e14\u0e02\u0e32\u0e27\u0e21\u0e32\u0e40\u0e1b\u0e47\u0e19\u0e1e\u0e27\u0e01<\/p>","protected":false},"author":2,"featured_media":13356,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[159],"tags":[62,1168,1165,1171,1170,1169,1167,97,118,53,1166,260,93,735,90],"class_list":["post-13343","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatment-technology","tag-chg-cancer-center","tag-immune-checkpoint","tag-immune-escape","tag-m2-macrophage","tag-mdsc","tag-treg","tag-warburg-effect","tag-97","tag-118","tag-53","tag-1166","tag-260","tag-93","tag-735","tag-90"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts\/13343","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/comments?post=13343"}],"version-history":[{"count":0,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts\/13343\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/media\/13356"}],"wp:attachment":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/media?parent=13343"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/categories?post=13343"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/tags?post=13343"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}