{"id":13498,"date":"2025-05-12T18:59:42","date_gmt":"2025-05-12T11:59:42","guid":{"rendered":"https:\/\/chgcancercenter.com\/?p=13498"},"modified":"2025-05-12T19:44:36","modified_gmt":"2025-05-12T12:44:36","slug":"sorafenib-liver-cancer-treatment-guide","status":"publish","type":"post","link":"https:\/\/chgcancercenter.com\/en\/sorafenib-liver-cancer-treatment-guide\/","title":{"rendered":"Sorafenib: A Powerful Drug for Liver Cancer"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"13498\" class=\"elementor elementor-13498\">\n\t\t\t\t<div class=\"elementor-element elementor-element-53eb7dc6 e-flex e-con-boxed e-con e-parent\" data-id=\"53eb7dc6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1995faba elementor-widget elementor-widget-text-editor\" data-id=\"1995faba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h1><span style=\"font-size: 24pt;\"><strong>Sorafenib: A Powerful Drug for Liver Cancer<\/strong><\/span><\/h1><h2><span style=\"font-size: 18pt;\"><b>What is Sorafenib?<\/b><\/span><\/h2><p class=\"translation-block\">Sorafenib is an oral targeted therapy classified as a multi-kinase inhibitor. It works by blocking several key proteins involved in tumor growth and blood vessel formation (angiogenesis), such as<\/p><ul><li><span style=\"font-weight: 400;\">VEGFR<\/span><\/li><li><span style=\"font-weight: 400;\">PDGFR<\/span><\/li><li><span style=\"font-weight: 400;\">RAF kinases.<\/span><\/li><\/ul><p class=\"translation-block\">It can slow down the growth of the cancer and limit its spread to other organs.<\/p><h2><span style=\"font-size: 18pt;\"><b>Main indications<\/b><\/span><\/h2><p class=\"translation-block\">Used to treat patients with Hepatocellular Carcinoma (HCC) in cases where<\/p><ul><li><span style=\"font-weight: 400;\">The tumor is too large to be operated on (Unresectable HCC)<\/span><span style=\"font-weight: 400;\"><br \/><\/span><\/li><li><span style=\"font-weight: 400;\">The cancer has spread to other organs (Metastatic HCC)<\/span><span style=\"font-weight: 400;\"><br \/><\/span><\/li><\/ul><p><span style=\"font-weight: 400;\">It is also approved for:<\/span><span style=\"font-weight: 400;\"><br \/><\/span><\/p><ul><li class=\"translation-block\">Advanced Renal Cell Carcinoma (RCC)<\/li><li class=\"translation-block\">Anplastic or differentiated thyroid carcinoma (differentiated thyroid carcinoma unresponsive to iodine therapy)<\/li><\/ul><h2><span style=\"font-size: 18pt;\"><b>How to use the medicine<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Standard dosage: 400 mg twice daily (morning-evening) total 800 mg\/day<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Should be taken on an empty stomach or after a light meal to increase absorption.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Must be taken continuously until there is a reason to stop, such as severe side effects or a relapse of the disease.<\/li><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">The doctor may reduce the dosage to 200 mg per dose in cases where there are obvious side effects.<\/li><\/ul><h2><span style=\"font-size: 18pt;\"><b>Side effects to watch out for<\/b><\/span><\/h2><p class=\"translation-block\">Sorafenib has specific side effects that should be closely monitored, including:<\/p><ul><li><span style=\"font-weight: 400;\">Skin: Rash, Hand-Foot Syndrome, Skin ulcers<\/span><\/li><li><span style=\"font-weight: 400;\">Gastrointestinal system: Diarrhea, Nausea, Anorexia, Weight loss<\/span><\/li><li><span style=\"font-weight: 400;\">Blood pressure: Abnormally high blood pressure, regular blood pressure measurement<\/span><\/li><li><span style=\"font-weight: 400;\">Cardiac system: Risk of heart failure in some patients<\/span><\/li><li><span style=\"font-weight: 400;\">General: Fatigue, Abdominal pain, Partial hair loss<\/span><\/li><\/ul><p><b>Special Note:<\/b><\/p><ul><li style=\"font-weight: 400;\" aria-level=\"1\" class=\"translation-block\">Some cases may develop acute hepatitis, abnormal bleeding, or arrhythmias.<\/li><li><span style=\"font-weight: 400;\">Seek immediate medical attention if you experience shortness of breath, chest pain, or jaundice.<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-03fc15b e-flex e-con-boxed e-con e-parent\" data-id=\"03fc15b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-36c3cc6 elementor-widget elementor-widget-text-editor\" data-id=\"36c3cc6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><span style=\"font-size: 18pt; color: #000000;\"><b>Sorafenib's strengths<\/b><\/span><\/h2><p class=\"translation-block\">It is the first standard drug clinically proven to actually prolong the lives of patients with advanced liver cancer.<\/p><p><span style=\"font-weight: 400; color: #000000;\">Key studies:\u00a0<br \/><\/span><\/p><ul><li class=\"translation-block\">Sorafenib users lived an average of 2.8 months longer than those who did not receive the drug.<\/li><li><span style=\"color: #000000;\"><span style=\"font-weight: 400;\">Sorafenib significantly reduced tumor growth rate.<\/span><span style=\"font-weight: 400;\"><br \/><\/span><\/span><\/li><\/ul><p><span style=\"color: #000000;\"><span style=\"font-weight: 400;\">Therefore, Sorafenib has become the gold standard for patients with HCC that has progressed for many years.<\/span><span style=\"font-weight: 400;\"><br \/><\/span><\/span><\/p><h2><span style=\"font-size: 18pt; color: #000000;\"><b>Limitations you should know<\/b><\/span><\/h2><ul><li class=\"translation-block\">Not everyone responds equally well: Some patients have gene mutations or physical conditions that make the drug less effective.<\/li><li class=\"translation-block\">There are side effects that need to be closely managed, such as blood pressure control and skin wound care.<\/li><li><span style=\"color: #000000;\">\u0e21\u0e35\u0e17\u0e32\u0e07\u0e40\u0e25\u0e37\u0e2d\u0e01\u0e43\u0e2b\u0e21\u0e48\u0e41\u0e25\u0e49\u0e27<span style=\"font-weight: 400;\">: \u0e22\u0e32\u0e17\u0e35\u0e48\u0e1e\u0e31\u0e12\u0e19\u0e32\u0e43\u0e2b\u0e21\u0e48 \u0e40\u0e0a\u0e48\u0e19\u00a0<\/span><\/span><ul><li><span style=\"color: #000000;\">Lenvatinib<span style=\"font-weight: 400;\">: \u0e21\u0e35\u0e1c\u0e25\u0e25\u0e31\u0e1e\u0e18\u0e4c\u0e43\u0e01\u0e25\u0e49\u0e40\u0e04\u0e35\u0e22\u0e07\u0e2b\u0e23\u0e37\u0e2d\u0e14\u0e35\u0e01\u0e27\u0e48\u0e32\u0e43\u0e19\u0e1a\u0e32\u0e07\u0e01\u0e25\u0e38\u0e48\u0e21<\/span><span style=\"font-weight: 400;\"><br \/><\/span><\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"color: #000000;\">Atezolizumab + Bevacizumab<span style=\"font-weight: 400;\">: \u0e01\u0e32\u0e23\u0e23\u0e31\u0e01\u0e29\u0e32\u0e41\u0e1a\u0e1a\u0e20\u0e39\u0e21\u0e34\u0e04\u0e38\u0e49\u0e21\u0e01\u0e31\u0e19\u0e1a\u0e33\u0e1a\u0e31\u0e14 (Immunotherapy) + \u0e22\u0e32\u0e15\u0e49\u0e32\u0e19\u0e2b\u0e25\u0e2d\u0e14\u0e40\u0e25\u0e37\u0e2d\u0e14 \u0e01\u0e33\u0e25\u0e31\u0e07\u0e40\u0e1b\u0e47\u0e19\u0e17\u0e32\u0e07\u0e40\u0e25\u0e37\u0e2d\u0e01\u0e41\u0e23\u0e01\u0e43\u0e19\u0e2b\u0e25\u0e32\u0e22\u0e1b\u0e23\u0e30\u0e40\u0e17\u0e28<\/span><\/span><\/li><\/ul><\/li><\/ul><h2><span style=\"font-size: 18pt; color: #000000;\"><b>summarize<\/b><\/span><\/h2><ul><li class=\"translation-block\">Sorafenib is a revolutionary treatment for advanced liver cancer, but it requires careful monitoring for symptoms and side effects.<\/li><li class=\"translation-block\">The choice depends on the patient's condition, additional test results, and access to newer drugs.<\/li><li class=\"translation-block\">It should always be under the close supervision of a liver cancer specialist.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a93b92e e-flex e-con-boxed e-con e-parent\" data-id=\"a93b92e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-93ea625 elementor-widget elementor-widget-image\" data-id=\"93ea625\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"427\" src=\"https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/05\/Sorafenib_-A-Powerful-Drug-for-Liver-Cancer1.jpg\" class=\"attachment-large size-large wp-image-13513\" alt=\"\u0e2d\u0e34\u0e19\u0e42\u0e1f\u0e01\u0e23\u0e32\u0e1f\u0e34\u0e01\u0e2d\u0e18\u0e34\u0e1a\u0e32\u0e22\u0e02\u0e49\u0e2d\u0e04\u0e27\u0e23\u0e23\u0e39\u0e49\u0e40\u0e01\u0e35\u0e48\u0e22\u0e27\u0e01\u0e31\u0e1a\u0e22\u0e32 Sorafenib \u0e2a\u0e33\u0e2b\u0e23\u0e31\u0e1a\u0e23\u0e31\u0e01\u0e29\u0e32\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e15\u0e31\u0e1a \u0e23\u0e27\u0e21\u0e1b\u0e23\u0e30\u0e42\u0e22\u0e0a\u0e19\u0e4c \u0e1c\u0e25\u0e02\u0e49\u0e32\u0e07\u0e40\u0e04\u0e35\u0e22\u0e07 \u0e41\u0e25\u0e30\u0e41\u0e19\u0e27\u0e17\u0e32\u0e07\u0e43\u0e0a\u0e49\u0e2d\u0e22\u0e48\u0e32\u0e07\u0e1b\u0e25\u0e2d\u0e14\u0e20\u0e31\u0e22\" srcset=\"https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/05\/Sorafenib_-A-Powerful-Drug-for-Liver-Cancer1.jpg 800w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/05\/Sorafenib_-A-Powerful-Drug-for-Liver-Cancer1-300x200.jpg 300w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/05\/Sorafenib_-A-Powerful-Drug-for-Liver-Cancer1-768x513.jpg 768w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/05\/Sorafenib_-A-Powerful-Drug-for-Liver-Cancer1-18x12.jpg 18w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/05\/Sorafenib_-A-Powerful-Drug-for-Liver-Cancer1-600x401.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-12144cc e-flex e-con-boxed e-con e-parent\" data-id=\"12144cc\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0cd1af5 elementor-widget elementor-widget-video\" data-id=\"0cd1af5\" data-element_type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=tYxxR4VCDOU&amp;t=17s&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-32e8f1d e-flex e-con-boxed e-con e-parent\" data-id=\"32e8f1d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18e9011 elementor-widget elementor-widget-ct_text_editor\" data-id=\"18e9011\" data-element_type=\"widget\" data-widget_type=\"ct_text_editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"ct_text_editor-18e9011\" class=\"ct-text-editor wow fadeInUp\" data-wow-delay=\"ms\">\n\t<div class=\"ct-item--inner\">\n\t\t<div class=\"ct-inline-css\"  data-css=\"\t        \t\t\t\">\n\n\t    <\/div>\n\t\t<div class=\"ct-text-editor elementor-clearfix\">\n\t\t\t<p class=\"translation-block\">For inquiry, please call <a href=\"tel:0638166058\" target=\"_self\">+66638166058<\/a><\/p>\t\t\n\t\t<\/div>\n\t<\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc4a6ee e-flex e-con-boxed e-con e-child\" data-id=\"cc4a6ee\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c0616b5 e-con-full e-flex e-con e-child\" data-id=\"c0616b5\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e7c50bd elementor-widget elementor-widget-text-editor\" data-id=\"e7c50bd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-family: lineseedsansth;\">Request consultation for treatment plan<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9058c76 e-con-full e-flex e-con e-child\" data-id=\"9058c76\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d1e4874 elementor-widget elementor-widget-text-editor\" data-id=\"d1e4874\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/lin.ee\/sx9JJLJ\"><img decoding=\"async\" class=\"\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/th.png\" alt=\"\u0e40\u0e1e\u0e34\u0e48\u0e21\u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e19\" width=\"115\" height=\"36\" border=\"0\" \/><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-549157e e-flex e-con-boxed e-con e-child\" data-id=\"549157e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u0e40\u0e23\u0e35\u0e22\u0e19\u0e23\u0e39\u0e49\u0e02\u0e49\u0e2d\u0e14\u0e35 \u0e02\u0e49\u0e2d\u0e08\u0e33\u0e01\u0e31\u0e14 \u0e41\u0e25\u0e30\u0e1c\u0e25\u0e02\u0e49\u0e32\u0e07\u0e40\u0e04\u0e35\u0e22\u0e07\u0e02\u0e2d\u0e07 Sorafenib \u0e40\u0e1b\u0e47\u0e19\u0e22\u0e32 Targeted Therapy \u0e0a\u0e19\u0e34\u0e14\u0e23\u0e31\u0e1a\u0e1b\u0e23\u0e30\u0e17\u0e32\u0e19 \u0e22\u0e32\u0e23\u0e31\u0e01\u0e29\u0e32\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e15\u0e31\u0e1a\u0e23\u0e30\u0e22\u0e30\u0e25\u0e38\u0e01\u0e25\u0e32\u0e21\u0e17\u0e35\u0e48\u0e43\u0e0a\u0e49\u0e17\u0e31\u0e48\u0e27\u0e42\u0e25\u0e01<\/p>","protected":false},"author":2,"featured_media":13517,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[159],"tags":[62,384,97,1206,1209,67,1208,831,1205,1210,961,260,93,1207,90],"class_list":["post-13498","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatment-technology","tag-chg-cancer-center","tag-targeted-therapy","tag-97","tag-1206","tag-1209","tag-liver-cancer","tag-1208","tag-831","tag--sorafenib","tag-1210","tag-961","tag-260","tag-93","tag-1207","tag-90"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts\/13498","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/comments?post=13498"}],"version-history":[{"count":0,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts\/13498\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/media\/13517"}],"wp:attachment":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/media?parent=13498"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/categories?post=13498"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/tags?post=13498"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}