{"id":14153,"date":"2025-07-29T15:00:46","date_gmt":"2025-07-29T08:00:46","guid":{"rendered":"https:\/\/chgcancercenter.com\/?p=14153"},"modified":"2025-07-29T14:57:02","modified_gmt":"2025-07-29T07:57:02","slug":"combination-immunotherapy-cancer-treatment","status":"publish","type":"post","link":"https:\/\/chgcancercenter.com\/en\/combination-immunotherapy-cancer-treatment\/","title":{"rendered":"Can Combination Immunotherapy Really Treat Cancer?"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"14153\" class=\"elementor elementor-14153\">\n\t\t\t\t<div class=\"elementor-element elementor-element-53eb7dc6 e-flex e-con-boxed e-con e-parent\" data-id=\"53eb7dc6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1995faba elementor-widget elementor-widget-text-editor\" data-id=\"1995faba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h1><span style=\"font-size: 24pt;\"><strong>Can Combination Immunotherapy Really Treat Cancer?<\/strong><\/span><\/h1><p class=\"translation-block\">Combination immunotherapy refers to using more than one immune checkpoint inhibitor together\u2014commonly anti-PD-1 (e.g., nivolumab) and anti-CTLA-4 (e.g., ipilimumab)\u2014to strengthen the body\u2019s immune response against cancer cells.<\/p><h2><span style=\"font-size: 18pt;\"><b>What Types of Cancer Can Be Treated?<\/b><\/span><\/h2><h3 class=\"translation-block\">1. Melanoma<\/h3><p><span style=\"font-weight: 400;\">\u0e43\u0e0a\u0e49 <\/span>nivolumab + ipilimumab<span style=\"font-weight: 400;\"> \u0e40\u0e1b\u0e47\u0e19 first-line \u0e43\u0e19\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22 BRAF-negative \u0e2b\u0e23\u0e37\u0e2d\u0e1c\u0e39\u0e49\u0e17\u0e35\u0e48\u0e08\u0e33\u0e01\u0e31\u0e14\u0e44\u0e21\u0e48\u0e43\u0e0a\u0e49 <a href=\"https:\/\/chgcancercenter.com\/en\/targeted-therapy-metastatic-cancer-combination-2\/\">targeted therapy<\/a><\/span><\/p><p><span style=\"font-weight: 400;\">\u0e23\u0e32\u0e22\u0e07\u0e32\u0e19\u0e27\u0e48\u0e32 survival rate 10 \u0e1b\u0e35 \u0e2a\u0e39\u0e07\u0e16\u0e36\u0e07 52% \u0e2a\u0e33\u0e2b\u0e23\u0e31\u0e1a\u0e1c\u0e39\u0e49\u0e43\u0e0a\u0e49\u0e22\u0e32 2 \u0e15\u0e31\u0e27\u0e23\u0e48\u0e27\u0e21\u0e01\u0e31\u0e19<\/span><\/p><h3 class=\"translation-block\">2. Kidney Cancer (Renal Cell Carcinoma)<\/h3><p><span style=\"font-weight: 400;\">Nivolumab+ipilimumab \u0e44\u0e14\u0e49\u0e23\u0e31\u0e1a\u0e01\u0e32\u0e23\u0e23\u0e31\u0e1a\u0e23\u0e2d\u0e07\u0e43\u0e19\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22 metastatic \u0e01\u0e25\u0e38\u0e48\u0e21 intermediate\u2013poor risk<\/span><\/p><h3><span style=\"font-size: 14pt;\"><b>3.Non\u2011Small Cell Lung Cancer (NSCLC)<\/b><\/span><\/h3><p><span style=\"font-weight: 400;\">Approved for patients with PD-L1 \u22651%, or in combination with chemotherapy depending on stage and mutation profile.<\/span><\/p><h3><span style=\"font-size: 14pt;\"><b>4.Colorectal Cancer (MSI\u2011H\/dMMR)<\/b><\/span><\/h3><p class=\"translation-block\">Applicable to patients with MSI-H\/dMMR genetic profiles, which respond better to immune therapies.<\/p><h3><span style=\"font-size: 14pt;\"><b>5.Hepatocellular Carcinoma<\/b><\/span><\/h3><p class=\"translation-block\">May be used after progression on first-line targeted therapy like sorafenib.<\/p><h2><span style=\"font-size: 18pt;\"><b>Why Use Combination Therapy?<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dual checkpoint blockade enhances T-cell activation at different points in the immune cycle.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Provides more robust and durable responses compared to monotherapy.<\/span><\/li><\/ul><h2><span style=\"font-size: 18pt;\"><b>Precautions<\/b><\/span><\/h2><ul><li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">More severe side effects such as hepatitis, enteritis, thyroid problems, etc. require intensive monitoring and evaluation.<\/span><\/li><li style=\"font-weight: 400;\" aria-level=\"1\">It is recommended to be treated by an experienced team and have an automatic symptom tracking system.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-03fc15b e-flex e-con-boxed e-con e-parent\" data-id=\"03fc15b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-36c3cc6 elementor-widget elementor-widget-text-editor\" data-id=\"36c3cc6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><span style=\"font-size: 24pt; color: #000000;\"><b>The PDQ\u00ae approach recommends that there are multiple alignments available.<\/b><\/span><\/h2><p><span style=\"font-weight: 400; color: #000000;\">Combination immunotherapy is a powerful option for treating several types of advanced cancer. While more effective than single-agent therapy in many cases, it comes with increased risk of immune side effects. Personalized assessment by oncologists is essential before starting this treatment.<\/span><\/p><p class=\"translation-block\">If you or your loved one is considering immunotherapy, ask your doctor about combination checkpoint inhibitors and whether they are right for your case<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a93b92e e-flex e-con-boxed e-con e-parent\" data-id=\"a93b92e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-93ea625 elementor-widget elementor-widget-image\" data-id=\"93ea625\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"480\" src=\"https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/07\/Can-Combination-Immunotherapy-Really-Treat-Cancer1.jpg\" class=\"attachment-large size-large wp-image-14165\" alt=\"\u0e20\u0e32\u0e1e\u0e41\u0e2a\u0e14\u0e07\u0e01\u0e25\u0e44\u0e01\u0e02\u0e2d\u0e07 Combination Immunotherapy \u0e17\u0e35\u0e48\u0e43\u0e0a\u0e49\u0e2a\u0e32\u0e23\u0e22\u0e31\u0e1a\u0e22\u0e31\u0e49\u0e07 checkpoint \u0e2b\u0e25\u0e32\u0e22\u0e0a\u0e19\u0e34\u0e14\u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e01\u0e23\u0e30\u0e15\u0e38\u0e49\u0e19\u0e20\u0e39\u0e21\u0e34\u0e04\u0e38\u0e49\u0e21\u0e01\u0e31\u0e19\u0e43\u0e2b\u0e49\u0e15\u0e49\u0e32\u0e19\u0e40\u0e0b\u0e25\u0e25\u0e4c\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e2d\u0e22\u0e48\u0e32\u0e07\u0e21\u0e35\u0e1b\u0e23\u0e30\u0e2a\u0e34\u0e17\u0e18\u0e34\u0e20\u0e32\u0e1e\" srcset=\"https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/07\/Can-Combination-Immunotherapy-Really-Treat-Cancer1.jpg 800w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/07\/Can-Combination-Immunotherapy-Really-Treat-Cancer1-300x225.jpg 300w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/07\/Can-Combination-Immunotherapy-Really-Treat-Cancer1-768x576.jpg 768w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/07\/Can-Combination-Immunotherapy-Really-Treat-Cancer1-16x12.jpg 16w, https:\/\/chgcancercenter.com\/wp-content\/uploads\/2025\/07\/Can-Combination-Immunotherapy-Really-Treat-Cancer1-600x450.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-32e8f1d e-flex e-con-boxed e-con e-parent\" data-id=\"32e8f1d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18e9011 elementor-widget elementor-widget-ct_text_editor\" data-id=\"18e9011\" data-element_type=\"widget\" data-widget_type=\"ct_text_editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div id=\"ct_text_editor-18e9011\" class=\"ct-text-editor wow fadeInUp\" data-wow-delay=\"ms\">\n\t<div class=\"ct-item--inner\">\n\t\t<div class=\"ct-inline-css\"  data-css=\"\t        \t\t\t\">\n\n\t    <\/div>\n\t\t<div class=\"ct-text-editor elementor-clearfix\">\n\t\t\t<p class=\"translation-block\">For inquiry, please call <a href=\"tel:0638166058\" target=\"_self\">+66638166058<\/a><\/p>\t\t\n\t\t<\/div>\n\t<\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc4a6ee e-flex e-con-boxed e-con e-child\" data-id=\"cc4a6ee\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c0616b5 e-con-full e-flex e-con e-child\" data-id=\"c0616b5\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e7c50bd elementor-widget elementor-widget-text-editor\" data-id=\"e7c50bd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-family: lineseedsansth;\">Request consultation for treatment plan<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9058c76 e-con-full e-flex e-con e-child\" data-id=\"9058c76\" data-element_type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d1e4874 elementor-widget elementor-widget-text-editor\" data-id=\"d1e4874\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/lin.ee\/sx9JJLJ\"><img decoding=\"async\" class=\"\" src=\"https:\/\/scdn.line-apps.com\/n\/line_add_friends\/btn\/th.png\" alt=\"\u0e40\u0e1e\u0e34\u0e48\u0e21\u0e40\u0e1e\u0e37\u0e48\u0e2d\u0e19\" width=\"115\" height=\"36\" border=\"0\" \/><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-549157e e-flex e-con-boxed e-con e-child\" data-id=\"549157e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u0e01\u0e32\u0e23\u0e43\u0e0a\u0e49\u0e20\u0e39\u0e21\u0e34\u0e04\u0e38\u0e49\u0e21\u0e01\u0e31\u0e19\u0e1a\u0e33\u0e1a\u0e31\u0e14\u0e23\u0e48\u0e27\u0e21\u0e01\u0e31\u0e19 (Combination Immunotherapy) \u0e04\u0e37\u0e2d \u0e17\u0e32\u0e07\u0e40\u0e25\u0e37\u0e2d\u0e01\u0e43\u0e2b\u0e21\u0e48\u0e02\u0e2d\u0e07\u0e1c\u0e39\u0e49\u0e1b\u0e48\u0e27\u0e22\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e40\u0e21\u0e25\u0e32\u0e42\u0e19\u0e21\u0e32 \u0e44\u0e15 \u0e1b\u0e2d\u0e14 \u0e41\u0e25\u0e30\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e25\u0e33\u0e44\u0e2a\u0e49\u0e1a\u0e32\u0e07\u0e0a\u0e19\u0e34\u0e14<\/p>","protected":false},"author":2,"featured_media":14169,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[159],"tags":[1354,62,1353,1355,936,97,127,61,1350,766,961,260,93,90],"class_list":["post-14153","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-treatment-technology","tag-checkpoint-inhibitor","tag-chg-cancer-center","tag-combination-immunotherapy","tag-ipilimumab","tag-nivolumab","tag-97","tag-127","tag-lung-cancer","tag-1350","tag-766","tag-961","tag-260","tag-93","tag-90"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts\/14153","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/comments?post=14153"}],"version-history":[{"count":0,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/posts\/14153\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/media\/14169"}],"wp:attachment":[{"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/media?parent=14153"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/categories?post=14153"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chgcancercenter.com\/en\/wp-json\/wp\/v2\/tags?post=14153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}