Is Modified Radical Mastectomy (MRM) Still a Standard Treatment for Breast Cancer
What is Modified Radical Mastectomy (MRM)?
Modified Radical Mastectomy (MRM) is a surgical procedure for .Breast cancer .With the removal of the breast and lymph nodes in the armpit, there are currently many advances in breast cancer treatment, especially Breast conserving surgery (Breast-Conserving Surgery – BCS) in conjunction with .treating cancer, which studies confirm provides survival rates comparable to total mastectomy in early-stage breast cancer. However, MRM remains an essential option for certain clinical indications.
Indications for Modified Radical Mastectomy (MRM)
- Locally Advanced Breast Cancer – When breast-conserving surgery is not feasible, even after neoadjuvant chemotherapy.
- Multicentric Disease – Presence of cancer in multiple distinct areas of the same breast, making BCS impractical.
- Persistent Positive Margins – When cancer cells remain at the surgical margins despite multiple attempts to achieve clear margins.
- Inflammatory Breast Cancer – Generally treated with neoadjuvant chemotherapy followed by MRM.
- Patient Preference – Some patients opt for MRM to reduce the risk of recurrence and avoid radiation therapy.
- Contraindications to Radiation Therapy – Cases where radiation is not advisable due to prior chest irradiation or connective tissue disorders sensitive to radiation.
Comparison: MRM vs. BCS + Radiation Therapy
- MRM: Recommended for patients with specific clinical indications and those who prefer a lower recurrence risk.
- BCS + Radiation Therapy: Preferred for early-stage breast cancer as it preserves breast shape while providing effective disease control.
While BCS combined with radiation therapy remains the primary treatment for early-stage breast cancer, MRM remains an essential option or patients with specific clinical needs. The treatment decision should be based on cancer characteristics, patient health, and individual preferences. A multidisciplinary team should guide the treatment plan to achieve the best outcomes for each patient.
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